The sermon traces the first missionary journey of Paul and Barnabas, emphasizing the divine orchestration of the gospel's expansion from Jerusalem to Antioch in Syria and then to Cyprus, Perga, and Pisidian Antioch, where Paul delivers his first recorded sermon. Centered on Acts 13–14, the message highlights how Paul, though initially focused on Jewish audiences and the synagogue, progressively reveals the continuity between the Old and New Testaments, grounding his preaching in God's redemptive history from Abraham to John the Baptist, culminating in the fulfillment of salvation through Christ. Despite initial acceptance by both Jews and God-fearers, the response turns hostile as Jewish opposition intensifies, leading to persecution, division, and Paul's eventual departure to Iconium, Lystra, and Derbe, demonstrating that the gospel's advance is not hindered by resistance but is sovereignly guided by divine providence. The journey underscores the universal scope of the gospel, the cost of discipleship, and the enduring truth that the kingdom of God, though often opposed, cannot be moved.